Free health results from your DNA test for the rest of 2019

Dec28

There is a third party site which will analyze your DNA test results for health information called Promethease which is FREE until the end of the year as a gift to us from MyHeritage who has acquired that site. You can even upload several tests from different companies for the same person to get a more complete picture.

Looking at your results takes some getting used to. It is a fairly geeky interface but here is a video that explains it.

 

They only keep the report for 45 days, but you can download it to your computer for future viewing.

Please be aware that the problem with trying to get health results from your DNA test is that so little is yet known. While some of the most damaging mutations are well documented there are hundreds more that might or might not be a problem. Most evidence is from correlation studies which are not necessarily definitive or large enough to be statistically significant.

On the front page you may quickly agree to many terms and conditions but please read and understand this one,

“I realize that most published reports about DNA variations explain only a small part of the heritability of a trait, and they also don’t take into account how different variants might interact. In addition, published reports typically ignore environmental, dietary, microbial, medical history and lifestyle factors, any or all of which may well affect my true risk for any trait or disease. “

Reading some of the information Promethease shows for your genes can be scary but don’t be alarmed. Most of these results are just saying that you might have an increased tendency for a specific condition but please remember that genes have to interact with each other and your enviroment so most are not destiny by themselves.

Here is an example of how it works:

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Important Changes at GEDmatch

Dec17

If you have not logged into GEDmatch recently, please do so and either accept the new terms and conditions or don’t. Unless you are clearly USA based*, your kits will not be visible to your relatives any more unless you accept. I have linked to numerous other blogs at the end of this article to help you make your choice. I recommend reading either the one from Roberta Estes or EU users, the one from Debbie Kennett. Both look carefully at the new terms and conditions which are not very different from before.

Frankly, I was surprised by the panic expressed last week by some in the genetic genealogy world on FaceBook due to the sale of our beloved GEDmatch DNA tools site to a forensic science company. Personally, I hate knee jerk reactions so I did some research into this company, Verogen, as well as communicated extensively with Curtis Rodgers, one of the GEDmatch founders, and Kim Mohr, a spokesperson for Verogen.

To remind you all, GEDmatch is the best place to compare DNA tests done at different companies to each other or just to see the actual chromosome locations shared by two Ancestry testers. While both Family Tree DNA (ftDNA) and MyHeritage accept uploads of tests from other companies so you can compare on those sites, neither has the extensive tools of GEDmatch. FtDNA compares down to very small segments which can be useful in a family project but leads to inaccurate relationship estimates. MyHeritage does not show the X chromosome and neither company shows the fully identical segments (FIRs) that full siblings will have, which can be so helpful (click here).

The DNA Applications menu at GEDmatch

GEDmatch has many useful additional tools, such as “People who match both or 1 of 2 kits ,” an “Are your parents related?” test, the ability to see who matches you on a specific segment, being able to check for full siblings rather than half, and automated triangulation, to name a few of my favorites (click those words to go to that post when I did one or click here for my more general GEDmatch articles). Plus it has GEDCOM comparison utilities. Compare yours to all the ones in the database or to just one other.

GEDmatch became a center of controversy when it was discovered that genetic genealogist Barbara Rae-Venter, working with law enforcement (LE). had solved the Golden State Killer case (click here) using that site. Since that time, there have been more controversies around law enforcement’s use of the site and many overblown scare articles in the press. Personally if my DNA outs a distant cousin who is a murderer or rapist, that’s fine with me. Genetic genealogy techniques are used as a tip; no one is arrested without getting their DNA from discarded materials and seeing if it is a match to the crime scene. I know some people are afraid of the possibility of false arrests, but that just does not happen with these modern techniques. You can, as before, choose to opt out of allowing LE to see your results on GEDmatch when looking for cousin matches to the dna of the perp or the unidentified victim.

In recent months, there have been more problems, news stories and controversies, including a Florida search warrant being granted. One has to feel for the two retired hobbyists who founded GEDmatch to help in their research and ultimately help us all, keeping most of the features free. Clearly getting the site owned and managed by a more professional group would be of great advantage to the users. Curtis spent several months looking for the right partner that would respect the original misson of GEDmatch and yet deal appropriately with LE, the EU, and security issues. He and the programmers, the two Johns, will continue to work on the site as consultants.

So who or what is Verogen? Two years ago this company was spun off from Illumina (the maker of the chips and machines that all the consumer oriented DNA testing companies use to sequence your DNA). It has 50 plus employees and plans to continue growing. Their office is in a small office park near UCSD here in San Diego. Continue reading →

Can ethnicity help with unknown parentage?

Dec5

Recently ethnicity was a major factor in figuring out the family of the mystery father of an Australian women of mixed heritage: Chinese, Italian, and English/Irish.[UPDATE 4-APR-2020: no help needed, all resolved now.]We still need some help, so any Australian readers please read to the end.

Elana’s ethnicty on Ancestry after the update, before she had lots more Italian

This case is unusual because for those of us with primarily European ancestry, the ethnicity predictions from the various DNA test companies are not accurate enough to be a significant aid with figuring out unknown parentage situations. For one thing, our ancestors moved around more than you might expect, and for another, the science is just not exact enough yet.

Too often I get a panicked email or comment from someone who is worried that Daddy is not their dad, or perhaps grandad is not, because their ethnicity predictions show no German or French or Bulgarian which he was and where is that Norwegian from? To which I respond, check your matches, if you have matches to cousins from his family, all is well, it’s just the inaccuracy of ethnicity predictions. North Europeans and South Europeans are fairly distinct from each other, but countries as we know them today did not exist in the far past.

Comparing ethnicities for Elana (left) and her mother (right) at Ancestry

In Elana’s case, having East Asian and Southern European in addition to the usual Australian British mix, actually gave us some different and potentially useful data to work with. Her mother seemed entirely English, Welsh, Scottish and Irish, a frequent blend for an Australian. She remembers that Elana’s father said he was part Maori and that his name was Bob. There is no Maori in her results shown above (it usually looks Polynesian), so likely he was just trying to make himself seem exotic and interesting.

Elana’s best matches at ancestry were almost all maternal (yes this is a squashed image)

Since Elana’s mother tested also, we could see that Elana had no close matches that were not listed as “Mother’s side” on Ancestry which made the search very difficult. Her paternal matches consisted of only one 3rd cousin, an American of Italian ancestry, and lots of 4th cousins, quite a few with trees, and most of the closer ones were of Italian descent, in spite of only 7% Italian listed in her Ancestry ethnicity.

One possibility for so few paternal matches was related parents. We checked that by uploading to GEDmatch.com (click here for my post on related parents) and that was not the case. The other more likely explanation was very few of her father’s relatives had tested. For example, Elana had only one very distant Asian match in spite of her father clearly having half that heritage.

Since we could see both Elana’s ethnicity and her mother’s it was easy to tell that Elana’s unknown father was half Chinese/Korean with an Italian (great) grandparent. These were her initial percentages before the recent update at Ancestry:

65% England/Scotland/Wales (so her father will have about 15%)
16% Korea and Northern China
12% China
7% Italy

I asked Elana to also test at 23andme and to upload her Ancestry results to MyHeritage and Family Tree DNA as well. Still no luck finding close paternal matches.

 

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Thankful for my slow cooker and more

Nov28

I have so many things to be thankful for, starting with living in a place with great weather, good friends, fresh herbs in my garden, a view, and abundant local produce. I am also very thankful for the internet and Google which have helped my genealogy research enormously. I could go on endlessly with my thanks, but this holiday makes me think of food, so today I will blog about cooking.

About a year ago a friend gave me her old slow cooker, as she was getting a larger one. What a great gift this has turned out to be! This is such a convenient way to make dinner, almost no stirring over a hot stove, so little time to prepare it, and so wonderful to eat. Since I work out of a home office, I can throw the ingredients together in the morning or at lunch and then forget about it. Yes I love stew.

When my cousin was visiting last weekend I started Mexican beans in the morning before I left to take her to the ocean. I called my husband on the way home and asked him to put a bag of rice on. Another convenience to be thankful for! When I got home I made some cauliflower in the microwave and grated some cheese. An excellent dinner was ready in no time.

That Mexican bean recipe was an internet find at Mom’s Kitchen Handbook (click here), no soaking the beans overnight instead you just cook them on low for a long time. Good for three meals for us.

All my slow cooker recipes are from the internet. What I do is print them out, add any notes about changes I made, then if they work well, I add them to my book, one of those presentation binders with many clear pages that you can slip printouts into.

Most of the dinners that I cook in the slow cooker can feed many more people than the two of us, so I freeze up one and two person servings for another day. That way, when I am in a time crunch for a deadline I can just defrost my own cooking. Plus when I leave town, my husbands meals are all taken care of.

Warning, we have changed our diet over the last few years to be mainly plant based and full of healthful cancer fighting food (click here for Dr Li’s Eat to Beat disease website).

Here are some of my favorite slow cooker recipes:
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Clicking Over from DNA Ancestor Hints

Nov20

The great new features just keep coming for Ancestry‘s DNA product. Now we can click new people into our tree from a DNA match with an Ancestor hint. This can be done from the page where it shows the pathway for each of you to the common ancestor, explained in detail on the next page of this post. Hopefully you will all be careful about this, checking sources and so forth …

One thing I love about Ancestry‘s common ancestor feature is that it always uses my tree first before extrapolating from other trees and records. Yes that’s right, it uses records!

When I look at a DNA match with a common ancestor I always note the relationship in the notepad and then color code by great grandparent line. This means that when I look through my DNA matches with common ancestors, the ones not yet categorized are easy to see since they have nothing added in the right hand column, for example Susan in the diagram above.

The other approach would be to filter by “Matches you haven’t viewed” and visually scan for common ancestors since you cannot combine those filters. [UPDATE 22-Apr-2020: they can now be combined, Ancestry now has a better menu bar than the one shown above with more ways to view your matches] Personally I have too many distant cousins that I have not looked at yet, but I often use the group filter of “Close matches – 4th cousin or closer” and combine it with the sort by date. People who have just gotten their test results are more likely to be on the site and thus may respond to your message.

The problem with the latter approach is that some matches you have already viewed may have recently added some tree information and Ancestry has found a common ancestor that was not there before. Therefore it is best to add notes and/or color codes and periodically check the list of people with common ancestors for new finds.

The other day I saw a very fanciful looking match with distant cousin “A” to my VE line from Hordaland. Her ancestry was almost entirely Norwegian with a bit of Swedish so that fit. Curious about an ancestor called just “J” in her line I had to investigate.
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