Klotho – a gene for longevity and better brain function as you age

A recent discovery in the news is the Klotho gene which seems boost brain function and adds to longevity. About one in five people have the good variant.

KLsnpIf you tested at 23andme, you can find out if you have it by checking the SNP at rs9536314, the protective variant is the heterozygous one, GT, while the normal variant is TT. The homozygous version, GG, appears to be deleterious.

So log into your 23andme account and then click this URL to see if you have the GT  version is

Here are a few informative news articles explaining this discovery:

Now to get more technical.

Here are a few more techical links


On the GENEALOGY-DNA group at Rootsweb our resident expert Ann Turner looked into this for us and said

“The full text for the technical article, [subscription required], is here:


The nomenclature for this variant seemed odd to me, so I searched further
back in the literature and found an explanation dated 2001. It turns out to
be a haplotype (a set of variants on one chromosome). This old article does
state that the markers are in complete linkage disequilibrium in their
study population. If that holds up in subsequent studies, then a G for
rs9536314 would predict a C for rs9527025, and you would have the KL-VS


“These results precipitated a search for functional variants of klotho. We
identified an allele, termed KL-VS, containing six sequence variants in
complete linkage disequilibrium, two of which result in amino acid
substitutions F352V and C370S.”

Note also that the homozygous version of the KL-VS variant appears to be

2 thoughts on “Klotho – a gene for longevity and better brain function as you age

Click here to add your thoughts at the end of the comments
  1. Hello! Thank you so much for this useful information. I downloaded my raw data from 23andme and searched for rs9536314 but nothing came up. Do you think this means that its not a thorough report? Thanks!

    • They changed the URL for searching your genome. I have corrected it above. Just click it.
      Which chip version do you have (when did you test)? Perhaps it is not tested in the oldest chips.
      I also checked my Ancestry raw data and it is included there but not in my brother’s test which was the previous chip.

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