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23andme: Now and Then

23andme started out by being a leader in the direct-to-consumer (DTC) genomic testing business. Time Magazine named it the 2008 Invention of the Year![1] It was the first place I tested my own autosomal DNA and that of many family members back in 2011-2012. Originally it had the best cousin matching tools, best ethnicity estimates, and had a well designed interface to examine the health implications in your own genome. Now I recommend to most that they start with Ancestry DNA and then upload that data to several other sites, including Promethease for the medical analysis, although 23andme still tests a wider range of health related genes.

23andme has been in the news this week because its entire board, except its founder, Anne Wojcicki, resigned over her plan to take it private again. It went public in 2021 but has yet to turn a profit and the WSJ reports that it will run out of cash next year [ref WSJ]. However there is at least one company interested in buying it according to a post on the DNA-Newbie list.

How should those of us who have tests there react to this news? Personally I am not worried, mainly because I hardly ever use the site anymore. I have long since downloaded my data and have contacted most of my closer matches. Roberta Estes has done a thorough blog post (click here) explaining how to save your data from 23andme.

The reason I rarely use 23andme is because it no longer allows you to compare your DNA to a relative in a chromosome browser; the feature I liked the best. I now do that at GEDmatch, Family Tree DNA, and MyHeritage. That tool was removed because of a data breach over a year ago where a hacker got lists of Jewish and Chinese testers and posted them for sale on the dark web. The break-in took advantage of users who had the same email and password on multiple sites, some of which had been exposed elsewhere.

Perhaps it is the resulting class action suit that caused part of 23andme’s financial woes. Click here for an article about how that is being settled with users.

My understanding was that the inspiration for the founding of 23andme was that Genia Brin, the mother of the then husband of founder Anne Wojcicki, was diagnosed with Parkinson’s in 1998 [ref michaelfox org]. The focus of 23andme has always been on discovering the genetic basis of various medical issues, not genealogy. However they have been quite supportive of adoptees (click here), since it is helpful to know what issues may lie in your DNA when you have no known family health history.

One way to look at the genetic basis of various diseases is to crowd-source lots of genomes.

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Riding the Rails

​One of the benefits of doing genealogy is seeing history through the eyes of your ancestors. Sometimes helping another with their family history has a similar advantage. Cathie’s father wrote up his experiences in the 30s for her. I was so charmed by them that I asked for permission to publish a slightly edited and condensed version on my blog. Here it is:

I left home when I was just 16 in June of 1929. I worked on a farm, a golf course and spent the winter in a home for homeless boys in Chicago until clement weather arrived.

I then “rode the rails” with a vengeance when real Spring weather arrived — April or May 1930. I had made up my mind I wanted to reach the West Coast to become an apprentice seaman and, (for some obscure reason), to reach Japan.

Let me digress here a moment. Hitchhiking was the optimum way of traveling for a “wanderer” (later, a “bum”) in densely-populated areas. One could get to the outskirts of a town or city easily and there was considerable traffic from whom rides could be cadged ​with the thumb. But when it came to crossing the vast distances of the West, freight trains were the only answer. (You could starve to death hitchhiking in say, Wyoming or Nevada.)

So I took up “riding the rails”. ​It was not easy. You had to find the freight yards, seek out​ other bums who were going to take the next west-bound freight to assure yourself you had the​ right train and then position yourself strategically between where the train was made up, beyond​ where the railroad “dicks” kept the train under surveillance but still close enough to its point of​ origin before it reached dangerous speed. Then jumping into an empty car was no simple task.​ The outside door latch had to be​ unfastened, the door pushed open; then you used both your​ arms to lift yourself so you could slide on your stomach into the car. If your travelling​ companions had already gotten into the cars, they would give you a hand thus making the entry​ in a lot easier.

One had to be prepared for the monotony of hours, or days of travel. The scenery was generally​ entrancing. Freight trains stopped a lot, as you could dismount and stretch your legs or seek​ out a drinking water source. The brakemen riding in the caboose knew they had unauthorized​ passengers but normally took no adverse action against them. Chasing bums off trains “was not​ their job” (they left that to the railroad dicks).

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Using AI for Genealogy by Steve Little

One of the most unusual talks at the recent i4GG conference (videos coming soon) was the one about the use of AI for genealogy by Steve Little, the AI program director for the National Genealogical Society (NGS).  I learned that it was how you phrased your question that could lead to more accurate answers, e.g. “you are a professional genealogist … ” I found out that AI, particularly the paid versions, could extract text from documents, even handwritten ones and translate in context. Here is my favorite slide from that talk. Personally my first impression of ChatGPT had been that it was great at sounding good while making stuff up.

Slide from Steve Little’s talk, used by permission

Steve will be speaking at RootsTech at 8 am Thursday this week and will also be available at the NGS booth as per his post on FaceBook.

Amusingly, in my own talk about using bioancestry to solve unknown parentage cases, I had experimented with using AI generated images to illustrate a few of my points. For example, when I asked the deepAI image generator for a Hungarian violinist I got this image whose hands are imperfect, but it still adds pizzazz to the slide.

No sooner has my favorite DNA conference (i4GG) ended, than it is time to get ready for Rootstech! No I won’t be there in person this year, too much to do to prepare for our move to Connecticut. Hope everyone has a great time. I will attend virtually, so if you are logged in there, you can click here to see if you are related to me! As all my ancestors are fairly recent immigrants (earliest 1860s), I have only 434 relatives at Rootstech, the closest being a fifth cousin. Oh well.

My Ellis Island Visit: ​Anger Towards Immigrants is Nothing New!

Ellis Island has wonderful displays about immigration to America going back to the land bridge; even though it itself was only used from 1892- 1924. Although it did not close until 1954, in those later years it was only used for exceptional cases, since screening was done at the other end. This came about due to the increased restrictions on immigration (see list at the end of this article), most importantly the National Origins Act of 1924. Click here for the history of Ellis Island and click here for the BBC series of articles “The Open Door policy and immigration to 1928.”

The displays at Ellis Island have photos and letters and recorded voices but what struck me the most was the fact that there were so many anti-immigrant demonstrations back in the 19th century. I learned about them from an exhibit on the 2nd floor and thus learned that that sort of sentiment is not new. First it was the Irish immigrants, then the Chinese, then the Southern Europeans, and so on. There was the No Nothing party and the Nativists in the mid 1800s (click here for an article on the Know Nothings). I don’t remember much of this from my high school American history classes. Was it even covered to the extent shown on those walls?

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Conferences Galore!

The largest genealogy conference in the world, Rootstech is virtual and free again this year. It starts in just a few hours!

For genetic genealogists, i4GG is on again for April 9-10 in San Diego in person, thanks to CeCe Moore. The East Coast is going to have its own genetic genealogy conference, now virtual, ECGGC on April 23-24. Click any name in the preceding to go to the conference site and yes I will be presenting at all of them.

For Rootstech, my recorded talk delves into the details of the case where I found a jewish sperm donor; click here for that or here for the blog post. My very basic talk on using DNA to figure out unknown parentage, which I did for them last year, is still on youtube (click here). Roberta Estes has written a number of helpful posts about Rootstech 2022 – one on how to navigate the website and find what you want (click here) and several on using the find your relatives app  (click here and here)

For i4GG I usually present what’s new at GEDmatch and sometimes more about the latest tools for finding unknown parentage. My 2020 live i4GG talks can still be purchased with all the other great ones from that wonderful last conference before COVID at https://i4gg.org/2020-videos/

At the brand new East Coast Genetic Genealogy Conference (ECGGC), I will give some of my favorite and newly revised talks, live but virtual. The titles below link to the previous versions of my slides but I will make a note here when the slides are updated.

Getting the scoop on new GEDmatch features over lunch with Verogen’s Tom and Brett