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Big changes coming at 23andme, Health is back

Oct21
23andMe Utube

Excerpt from the 23andme Reports Overview at Youtube

The price has gone up but so has the amount of information you will receive. Those of you who bought kits after the FDA shut down the health information at 23andme will now get the new improved reports. All of us testers will receive an email once our accounts have transitioned over.

I received 12 emails today announcing this! As soon as any of the accounts I manage transition over to the new software, I will write a report here on my blog. The accounts that already had health reports were promised in the email that they will “continue to have access to [their] current health reports. The new experience will include redesigned versions of many of the same health and ancestry reports that you currently have.”

Blogger Andrea Badger published the following report on the DNA-NEWBIE mailing list:

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MyHeritage is now doing the family trees for 23andme

Jan19

So what is the impact of MyHeritage doing the family trees for 23andme? We can all agree that the previous family trees at 23andme were difficult to use. So this has to be an improvement, right? Maybe not.

To try it, I connected my own 23andme account to my existing MyHeritage tree and then looked at it from my aunt’s account, after logging out of MyHeritage. It was hard to find it on my profile. All the way at the very bottom were the words Family Tree next to which were the linked words View Kitty Cooper’s Family Tree. When I clicked on it I saw this:
KittyTreeMyHeritage

Oops. My Dad is set as the home person. Maybe Google can help me figure out how to change that. Clicking on the image above will take you to my tree so you can judge for yourself how well you like it.

MyHeritage is an excellent site in many ways, but to take advantage of the record matching you have to buy a premium membership. Also if you want more than 250 people in your tree, payment is required after those first free 6 months for 23andme folk. The premium or data membership gives access to many European records not on ancestry and also some newspaper articles I have not seen elsewhere.

For me, the biggest issue with MyHeritage is having no pedigree view on the family tree. When generation after generation had eight or more children, their tree view is very unwieldy.

In the rest of this post I will walk you step by step through setting up your 23andme tree at MyHeritage which you must do by May 1, 2015 to take advantage of the offer.
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Another way to triangulate: using close relatives

Jun6

I have been mainly working with my Dad’s Norwegian DNA at 23andme and at Family Tree DNA. Often he will have a match at one company and there will be a match to someone else on the same segment location at the other company. So how to tell if they match each other? Since one could have the DNA segment that Dad got from his mother and the other could have the segment Dad got from his father, the only way to be sure it is the same segment is if they also match each other on that segment. This is what is known as triangulation.

If they have both uploaded to GEDmatch, I can compare their two kits there and see if they match on that segment. Often however one or the other has not uploaded or the GEDmatch site is down. So I needed another way to figure this out.

It occurred to me that I could check if the new match also matches me there, since my results are at both web sites as well.

Obviously when they both match me on that DNA segment, I know they match each other. If one matches me and the other does not, then I know they are not a match. But what if they both do not match me? Then I must have inherited that segment from one of Dad’s parents and they are matching the DNA piece from his other parent.

In the case above, Dad has a 23cM match at Family Tree DNA with an adoptee at the same spot where he has many smaller matches over at 23andme. So do those folk match DM?

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Klotho – a gene for longevity and better brain function as you age

May11

A recent discovery in the news is the Klotho gene which seems boost brain function and adds to longevity. About one in five people have the good variant.

KLsnpIf you tested at 23andme, you can find out if you have it by checking the SNP at rs9536314, the protective variant is the heterozygous one, GT, while the normal variant is TT. The homozygous version, GG, appears to be deleterious.

So log into your 23andme account and then click this URL to see if you have the GT  version is
https://you.23andme.com/tools/data/?query=rs9536314&filter_by_platforms=true

Here are a few informative news articles explaining this discovery:
http://www.ucsf.edu/news/2014/05/114196/better-cognition-seen-gene-variant
http://www.medicalnewstoday.com/articles/276665.php

Now to get more technical.

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A Web Site with Tools for Y and other DNA analysis

Apr19

[UPDATE 18-Sep-2025] This tool is no longer available at that URL

There is a wonderful site at http://www.y-str.org with many good tools for Y DNA and autosomal DNA that run as programs on your PC plus a cool ISOGG Y tree add-on for the Chrome browser. My specific interest at the moment is figuring out which Y SNPs are already tested by 23andme so as not to test them again at FamilyTreeDNA since my Dad has kits at both places. I blogged about how to do that manually back in February, but now there is a program that will do that for you. However it took me a while to figure out how to do what I wanted from the instructions given, so I will do a step-by-step tutorial in this post in order to remember what I did.

BrowseMenuFirst download your raw data from 23andme by going to the “Browse Raw Data” Page which is listed in the menu that appears under your name on the top right. Then on the raw data page click on “Download” in the second top bar on the right hand side. This takes you to a page with various warnings and requires that you reenter your password as well as the answer to your secret question before it starts the download.

Save the download file somewhere that makes sense for you. I have a folder called RawData in the folder DNA that I use. Once the raw data file is downloaded, you will need to unzip it before using it with the various tools. To unzip in windows all you need to do is open a file explorer window (a manila envelope is the icon) and then right click on the file name to get a little menu that includes “extract all” which is the one to click.

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