There is a gene called CCR5 that can have a variation that prevents AIDS. You need to have two copies, one from each parent, to be immune to AIDS. If you have only one copy, your resistance is increased. The current theory is that this mutation became prevalent in Europeans after the ravages of smallpox or perhaps the Black Death and was selected for, since it is presumed protective against those diseases. It is more frequent in Northern Europe than Southern, but is found as far south as North Africa.
from wikipedia – By US National Institutes of Health – National Institute of Allergy and Infectious Diseases – US National Institutes of Health – National Institute of Allergy and Infectious Diseases, Public Domain, Link
The down side is that this CCR5 change may increase your risk of an abdominal aortic aneurysm and put you at risk for complications from various viruses like West Nile or tick born encephaliitis. Wikipedia has an excellent and detailed article about CCR5 here.
This AIDs protective variation is actually the loss of 32 alleles (so it is called delta 32) on chromosome 3 at location 46414947.
It is that change that the Genetics researcher He Jiankui claims to have made on two embryos in China using CRISPR technology which has caused such an uproar around the world. Click here for the NPR article about that which mentions that their father is HIV positive.
If you have tested your DNA at 23andme, you can check your own CCR5 for the delta 32 variation which is known as i3003626 there. Here’s how
Click on your name or image on the top left of any page at 23andme to get a drop down menu.
Then click on Browse Raw Data in that menu.
On the raw data page type i3003626 into the large box above the chromosome picture then click the enter key.
Here are examples of what you might see.
No deletes, so no delta 32 in this CCR5
One delete, so one delta 32 in this CCR5, resistant
AIDS immunity, two deletes, a Delta 32 from each parent
Some further reading, very technical:
https://www.snpedia.com/index.php/Rs333
Interesting. I didn’t do the 23andMe health test but uploaded my results to Promethease. My results said that while I’m not immune to HIV I have greater resistance to AIDS than most other people. I wonder if this is connected. 23andMe does say that I have more Neanderthal DNA than most testers. I read recently that Neanderthals would have had immunities or resistance to HIV.
As far as I can tell from looking at the raw data, only 23andme tests for Delta32 but there are other variants which confer resistance.
Yes Europeans inherited quite a bit of immune system help from Neanderthals but whether Delta32 was included is not known, just speculated on. Here is what we inherited…
https://www.uni-bonn.de/Press-releases/research-team-discovers-201cimmune-gene201d-in-neanderthals
I just did mine through prom as well. 90% reduction. All northern European with most recent ancestors from Sweden.
I was so surprised to see your post about this. I too have two copies! My ancestors are from Northern Ireland. I tried to research it but found little information other then what you have found. I wonder if having two copies would reveal any genealogy lines. I thought I read one 1 % of the population has 2 copies.
I don’t know that I have 2 copies, but I may have 1 as I’m apparently not immune, but would have a slower progression to AIDS. My father’s ancestors were from Northern Ireland.
All that can tell you is that each of your parents had at least one copy which is not much help for genealogy.
Isn’t following a genealogy line for AIDS resistant genes really creeping? There are no HIPPA laws protecting anyone.
So, in the first case:
“No deletes, so no delta 32 in this CCR5”
Does this mean that you are less receptive? Or more?
C –
What is unclear about “This AIDs protective variation is actually the loss of 32 alleles”? Therefore no deletes = no immunity from this particular genetic variation.
This news is on Fox today:
https://www.foxnews.com/health/london-patient-is-second-reported-patient-to-be-cured-of-h-i-v-report
Received a bone marrow transplant to address Hodgkin’s lymphoma. The donor had, you guessed it, both copies of the CCR5 mutation.
I have ccr5 delta-32. I am a gay man 70 years old I have a lover that is HIV positive.
Well that is a lucky mutation for you to have then.
I removed your email address from your post because I like to preserve privacy but if you really want the spam you will get, I can put it back!
The CCR5 delta 32 test on 23 and me result, what package is that result on, is it on the ancestry and health or only non the VIP. I am Northern European stock, my mothers side has been done through an Aunt but not my fathers. I would be interested in dna testing.
My family has been hit badly by cancer, rare forms too, I would certainly be interested in seeing possible markers for this.
Thanks
David,
Only 23andme shows the CCR5. I have not yet evaluated the Ancestr6 or MyHeritage health tests but the raw data from ancestry did not show the CCR5
If your family has been hit hard by cancer then you might talk to your doctor about doing the color genomics test which is specific for various cancer markers but needs doctor supervision. A friend with this same family issue and prostate cancer did that test which found a BRCA2 deletion not shown in his 23andme results.
I hope you know your stuff Kitty! The Ancestry Kit looked like it gave more SNPs for the $99 but I am specifically interested in the CCR5 since it may relate to COVID so I’ll try the 23andMe kit instead. They would not tell me straight out if the raw data still contained this or not so ty. @David, according to Promethease and https://www.snpedia.com/index.php/Testing
The 23andMe $99 “ancestry only” product and the $199 “ancestry + health” raw data is identical. So $99 it is lol.
The nice thing about 23andme is that you can browse the raw data if you are interested in that and yes it is the only company to test for this at the moment.
Thank you for posting this easy tutorial! Discovered that I have one deletion (heterozygous). Much gratitude.
I am looking to be tested. I had some very surprising test results recently. My husband of 27 years just gave me HIV. His test results indicates that he has had it for 12-18 months. Mine indicated I had it for a few weeks. I only found out because I had the flu really bad with severely swollen lymph nodes in my neck and an extremely swept throat. HIV-1 reactive and confirmed. The next set of tests which were drawn the day before I started meds, Al came back as though I didn’t have HIV, but more like fighting off the flu. The most interesting was the normal CD4 count and no viral load. The doctors are baffled. They said it looks like the virus was unable to infiltrate the CD4 cel’s and my immune system completely killed off the virus since it couldn’t replicate. In the last 18 month I have had these exact flu symptoms so I am thinking my husband keeps giving me HIV and I keep killing it off and we didn’t know because I didn’t know he had cheated/experimented with a man and contracted HIV. I have other mutations so I probably have this one too (homozygous MTHFR, homozygous MC1R, and numerous CYP450 mutations) A negative affect of all the mutations I have is that I have to take high doses of opioids more often than others, when I have to take them. On the plus side, I have no side affects and they don’t make me high. In 2016 Doctors had to give me 30 mg morphine every 2 hours for 6 months.
My sister told me today that she has declared that I am evolution.
EJ – well the 23andme test will show if you have the deletions on the CCR5 gene, sounds like you do. Lucky you!
I got my results and I had no deletions so I was disappointed not to have genetic superpowers but nothing bad showed up either and I enjoyed browsing the data. Thanks for the help! That was the the 23andMe $99 “ancestry only” with the raw data run through promethease.
Hi,
Are you saying that the deletions are shown as “-/-” in the column that says Your Genotype for marker i3003626?
This is all very confusing, and I’m just trying to make sure I understand what you are saying above. Many thanks.
Yes the deletion is shown as a dash as opposed to a bunch of letters
Thank you so much! You explained it perfectly but I just wanted to be sure.
I would like to be immune.
Hey Kitty ,
I used ancestrydna and it says 3003636 AA . What does this mean?
Rob –
Sorry, Ancestry does not give enough information about that location to determine if there is a deletion there or not. Notice that there are many letters shown for 23andme on that location….
Yes, Ancestry does give you enough info.
1. Download your data from Ancestry (Zip file, so unzip)
2. Open the text file in Pages or Excel, or just as a TEXT
3. CTRL + F (To find the gene) type or paste rs333 (Select whole words, this way it will only find exactly “rs333”.
4. Look to the right and you will either II, DI, or DD
The CCR5 gene (chemokine receptor type 5) codes for a protein on the cell membrane.
Base the results off of the guide below.
As for my I had the “DI” so I only have one deletion. Therefore I can get HIV but, it’s less likely and if I do get it then it won’t switch over to AIDS for quite awhile and even then I could survive to a ripe old age. Or whenever this cigarettes kill me
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II +/+: Not resistant to HIV infection; shows average time of progression to AIDS after infection.
DI Delta32/+: Not resistant to HIV infection but may have slower progression to AIDS after infection.
DD Delta32/Delta32: Resistant to infection by the most common strain of HIV people usually encounter, though protection is not complete.
Great, this must be on the newest chip, those of us with older tests do not have this information
I have several rs333… records. which is the one I’m looking for?
Since my mother had an abdominal aortic aneurysm (but lived to age 90 without it rupturing), I checked this gene, and discovered that I have one deletion, likely from my mother. Thanks for this post which made finding this so easy.