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Come celebrate DNA day with me!

This Friday is DNA Day; a day we honor the discovery of the structure of DNA. To mark this occasion, most of the personal DNA testing companies are having sales. There are also special events all over this country at museums, schools, and web sites. GEDmatch has a sale on for its premium tools plus I am doing a presentation there at 2 pm Eastern time on Friday.

Click image for the page at GEDmatch about its DNA day. At the bottom of the page is a link to register for my talk.

My last talk at GEDmatch was an attempt to make it easier to use the site by explaining the main tools and how to use them. That talk is still available — just click here. Of course, by now, the home page has changed and new features have been added.

Friday’s talk is focused on how I myself use GEDmatch when trying to understand a new match. In other words, why I ask my matches at other sites to upload to GEDmatch! I will also discuss some mysteries that the tools at GEDmatch have helped me solve. Last, but not least, I will answer questions from the audience. Hope to “see” you all there.

UPDATE: The presentation will be posted on the GEDmatch YouTube channel soon. The slides are available online at https://slides.com/kittycooper/advanced-tools-at-gedmatch-using-segment-data-and-more

Where personal DNA testing is today

All the DNA testing companies are still refining and improving their bio-ancestry estimates (which they call ethnicity). They are getting closer to agreeing with each other now, but that aspect of DNA testing is not yet a firm science. A number of companies have recently updated their estimates. Ancestry did a major update in October 2024 (click here for that white paper) and MyHeritage just did an update as well. The main effect on my family’s results is a far more accurate prediction of our Norwegian percentage. In the past, all the companies, except Ancestry, called our Norwegian Scandinavian and English. MyHeritage even gets the locations in Norway correct, since we have ancestors from 3 different areas. This is due to my grandad, born in Kristiansand, marrying the daughter of Norwegian immigrants (from Vestland and Hordaland) who met in Brooklyn.

Above are my brother’s current estimates with the new MyHeritage update. Since we have one German Jewish grandfather, I love to see how much each company assigns to Ashkenazi (northern European Jewish) for me and my brother. They all agree that I got about 8% more from our grandad than he did, but the exact amounts are different. Plus MyHeritage now breaks the Ashkenazi into Western and Eastern Europe. My brother got those refinements (added in to Jewish below) but I did not.

Our various bio-ancestries, note Family Tree DNA is actually called Scandinavian not Norwegian. Also the extra jewish regions for MyHeritage have been added back in.

In the past MyHeritage showed only 44% Scandinavian and 27% English/Irish/Scottish which did not fit with the fact that my Dad is Norwegian going back to the 1500s. Now they show me with 53% Norwegian and no British. Ancestry has long since gotten rid of the erroneous British etc. prediction (it’s now 1%) while Family Tree DNA still has that. Yes my ancestors visited the British Isles and undoubtedly left some genetic material … While he was still alive my Dad did a 23andme test and they predict 97.3 Scandinavian for him with the rest Finnish. Unlike MyHeritage and Ancestry, 23andme does not break down Scandinavian by country.

I have a previous blog post (click here) about our ethnicity percentages where I remind my readers that “Although you inherit half of your DNA from each parent, they do not have to pass you an equal amount from each of their parents.” As you can see above, my brother and I got different amounts from our Jewish grandfather.

As the experienced tester knows, it’s the relative matching where the companies excel, although the exact relationships of more distant relatives cannot be accurately predicted. Even close family relationships, like uncle versus half brother versus grandad, are not always clear. (Click here for my post on that). Looking at that person’s relationships to other family members plus age and location can often get you to an answer.

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What’s new at GEDmatch and i4GG

Every year genetic genealogists gather in San Diego in February for the i4GG conference founded by CeCe Moore and Dr. Tim Janzen. This year is the tenth anniversary and I am honored to be one of the presenters again. Click here for the i4GG web site.

In past years I have talked about the new features at GEDmatch. In 2022, this was a particularly dense lecture. (click here for the slides), as there were so many new and enhanced features. Clustering was taking the community by storm and GEDmatch has two versions of that, one of which even includes tree building.

{UPDATE 9 Feb 2024] My talk for i4GG this year is about how to use Ethnicity to solve DNA cases. This year, I will talk about GEDmatch yet again, but as there are fewer new features, I will include some of the ways that site has helped me solve DNA puzzles.

One nice new feature is that the site now sends you an email when you have a new match. You can select both the frequency of those emails and the match size which triggers an email.

Whenever I get a new match on the One-to-Many, the first thing I want to see is who else they match among my relatives, so it has always puzzled me why they did not include a button to do that. Needless to say this was a feature I requested. Now it is finally here! There is a column called ICW tool which has the word Match which when clicked takes you to the function People who match both, or 1 of 2 kits with the kit numbers filled in, ready to use.

 One-to-Many image showing new ICW tool

middle section of the free version of One-to-Many limited version

 

Come to my lecture to hear more!

Much Ado About DNA Hacking

The recent panic about hacking at 23andme in the press seems overblown to me. What exactly would someone do with my DNA? There is nothing in there of any monetary value nor do I have health risks that need to be private. Perhaps knowing which celebrities are Jewish or Chinese might be of use to some bad actors. The fact is that those lists are for sale on the dark web. Click here for an interesting article about that.
We have all been advised to guard our online privacy but our DNA is not our social security number nor our credit card so I am not worried about this yet. The hackers were able to use login credentials that were leaked from other sites to access those people’s accounts at 23andme. Then they could see information about other 23andme users whose DNA matched the compromised account. The type of information exposed was ethnicity, other relatives, and family tree information, plus whatever you said about yourself. This does not seem worrisome to me. My actual DNA was not exposed and even if it were, it would take a very DNA savvy hacker to use it to create a fake relative of mine.

Most of the DNA sites are now forcing two factor authentication (2FA) on their users when they log in. That is where a text or an email is sent to you when you log in to be sure it is you. This should prevent “credential stuffing” hacks in the future. If you try to log into 23andme, you will also discover that you must now change your password there. If your relative is deceased and their email of record is no longer available you may be out of luck. Perhaps customer service can help you.

Here is the text of the recent email all my Jewish accounts received:

“Specifically, there was unauthorized access to one or more 23andMe accounts that were connected to you through DNA Relatives. As a result, the DNA Relatives profile information you provided in this feature was exposed to the threat actor.”

The moral of this story is not to use the same passwords on more than one site. Several of my favorite passwords were leaked in various hospital system breaches. Google is kind enough to tell me when I try to log in to a site with a compromised password. My recommendation is to use several passwords which you vary by including a 2 or 3 character indicator of the site name.  So for example add “23m” somewhere in your 23 and me password. Most of us have browsers which remember our passwords for us and if they forget, we can use the forgot password link or have the site text us a code. I keep a text file of my passwords with written descriptions of which password used rather than spelling them out. Naturally I use unique, different, and difficult passwords with 2 factor security on sites that access money.

Personally, I am not leaving 23andme although I did change my password there. I am sad that many of the features that I love, like the DNA comparison tools, are temporarily closed down. I look forward to their return once the breach has been understood and dealt with.

Svante Pääbo wins the Nobel for his ancient DNA work

The Nobel Prize in Physiology or Medicine 2022 has been awarded to the man who figured out how to extract ancient DNA and even sequenced the Neanderthal genome with his team in 2010. According to nobelprize.org this was “for his discoveries concerning the genomes of extinct hominins and human evolution.”

Click the image below to see him discuss the implications of his work with Neanderthal DNA in his 2022 Linnaeus Lecture.

Svante Pääbo’s use of clean rooms and technology revolutionized the field of ancient DNA. Before his work it was considered impossible to get autosomal DNA from ancient remains. It was thought that one could only extract mitochondrial DNA. Click here for the Wikipedia detailed article about him.

Another wonderful resource is his autobiographical tale of sequencing the Neanderthal genome – Neanderthal Man: In Search of Lost Genomes 1st Edition.